The H5N1 Influenza Variant Fujian-Like Hemagglutinin Selected Following Vaccination Exhibits a Compromised Furin Cleavage
Identifieur interne : 001304 ( Main/Exploration ); précédent : 001303; suivant : 001305The H5N1 Influenza Variant Fujian-Like Hemagglutinin Selected Following Vaccination Exhibits a Compromised Furin Cleavage
Auteurs : Antonella Pasquato [Canada] ; Nabil G. Seidah [Canada]Source :
- Journal of Molecular Neuroscience [ 0895-8696 ] ; 2008-07-01.
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Abstract
Abstract: The outbreak of H5N1 avian influenza strains infectious to human has dire neurological and pathological consequences. This led to the massive vaccination of host poultry, resulting in a Fujian-like variant (vFJ) resistant to immunization with two mutations at the furin-processing site of hemagglutinin: loss of the P2 Lys and P9 substitution of Gln to Leu within the cleavage site. We synthesized 14mer peptides mimicking the processing site of Fujian-like strains. We found that the peptide with the vFJ sequence is less cleaved as compared to the parent FJ-derived peptide by furin at either neutral or acidic pH values. We hypothesize that the double hemagglutinin mutations in vFJ may result in viruses with less processed hemagglutinin, thereby providing a mechanism for evading immune neutralization.
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DOI: 10.1007/s12031-008-9052-z
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This led to the massive vaccination of host poultry, resulting in a Fujian-like variant (vFJ) resistant to immunization with two mutations at the furin-processing site of hemagglutinin: loss of the P2 Lys and P9 substitution of Gln to Leu within the cleavage site. We synthesized 14mer peptides mimicking the processing site of Fujian-like strains. We found that the peptide with the vFJ sequence is less cleaved as compared to the parent FJ-derived peptide by furin at either neutral or acidic pH values. 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